The enzymatic activity of the PDC is the determining factor of the serverity of disease and the age where the patients are confirmed suffering from PDCD. The earlier patients are suffering from PDCD the higher mortality they face. That is, patients suffering from PDCD during their prenatal period usually face death in early childhood. On the other hand, those who suffers from the disease at a later period will instead face spastic conditions and poor motor coordination but usually survive till they reach adulthood.
Categories of symptoms: neurological and metabolic.
Individuals with neurological onset of PDCD typically exhibit poor muscle tone, lethargy, seizures, and may develop severe mental retardation, blindness, microcephaly, and spastic damage to muscles and tendons.
Individuals with metabolic symptoms of PDCD usually have extremely high levels of lactic acid within the bloodstreams. Hence, causing high amounts of ammonia. This type of onset typically does not respond to medical treatment, thus, causing many patients to die in infancy.
Common signs include a complicated, difficult delivery, low birth weight, low Apgar scores, short neck, shortened limbs, bent fingers, club foot and ventricular septal defect. Unusual, dysmorphic facial features are sometimes associated with this disorder, such as an upturned nose, drooping eyelids, low-set ears, and a squinting appearance.
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