How the illness affect individuals?

Malfunction of the Krebs Cycle will lead the cell to undergo anaerobic respiration where by lactate fermentation occurs after glycolysis. This may cause accumulation of lactate resulting in lactic acidosis.

This results in the following symptoms:

• Poor feeding
• Lethargy
• Rapid breathing (ie, tachypnea)
  
  

Neurological damages

•  affect neuronal migration
•  affect axonal growth
• affected  cell-cell interactions
•  disordered neuronal cytoarchitecture
•  neuropil fibers in grey matter
•  reduced size of bundles
•  disorganization of fibers in white matter.
• myelin sheath insulating some nerves may be missing entirely
  

Poor neurological development results in following symptoms:

• Poor acquisition or loss of motor milestones
• Poor muscle tone
• New onset seizures
• Periods of incoordination (ie, ataxia)
• Abnormal eye movements
• Poor response to visual stimuli
  
  
  
  
  
  
  Sources:
  1.Richard E Frye. (2012). Medscape reference. In Retrieved from http://emedicine.medscape.com/article/948360-clinical
  2. Pritchard, J. (2011, May 04). A pyruvate dehydrogenase deficiency. Retrieved from http://www.livestrong.com/article/434370-a-pyruvate-dehydrogenase-deficiency/
  3. Pliss , L. State University of New York at Buffalo, School of Medicine and Biomedical Sciences. (2004).Biochemical and structural brain alterations in female mice with cerebral pyruvate dehydrogenase deficiency (15569252). Retrieved from NCBI PubMed website: http://www.ncbi.nlm.nih.gov/pubmed/15569252
  4.Casto, J. (2002). Pyruvate dehydrogenase complex deficiency disease. Retrieved from http://www.ehow.com/facts_5984398_pyruvate-dehydrogenase-complex-deficiency-disease.html
  
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